The Wan Lab is affiliated with the Department of Cancer Biology, Abramson Family Cancer Research Institute, Penn Epigenetics Institute, and Institute for Regenerative Medicine at the Perelman School of Medicine, University of Pennsylvania. We employ multidisciplinary approaches to investigate chromatin function and its dysregulation in cancer, with a particular emphasis on understanding how chromatin mechanisms regulate gene activity to impact cell fate control during tumorigenesis and metastasis. We are also actively engaged in translating basic mechanistic insights to the development of novel therapeutics.

Latest News

August 2026: Our spotlight titled ‘A New Phase in KRAS Signaling’ is now online! Check here to learn more

June 2026: Our study revealing how RNA reinforces condensate nucleation to amplify oncogenic transcription is now published on Molecular Cell! Check here to learn more

June 2026: Krista successfully defended her thesis, becoming the first Ph.D. student to graduate from the Wan Lab! Congratulations, Dr. Budinich!

In the Media

Interested in joining?

We are constantly looking for talented and passionate researchers (postdocs, graduate students, undergraduate and research technicians) to join our growing team! Please see Open Positions and contact Dr. Wan if interested.